Sunday, August 21, 2016

Episode 2: Hopefully I'll get a meeting


 

This week on the meme team, 2EZ4RTZ is the meme of the day. But in all seriousness this week has kinda been awkward for me. On one hand I read deep into the literature of my topic and realized the real world implications of it. On the other hand I really wish I could arrange a meeting with my professor to help me confirm my research and hopefully give me some guidance. I’ll talk about the first topic first.

So I read the literature I had available to me, and I figured out the real world implications of my research. Protein folding is not an easy process and nature has created all of the most efficient working proteins. All man made proteins have only been done on a small scale and these proteins are significantly less efficient then the wild types (originals). Eventually scientists were like wtf we can’t create any proteins we gotta find a cheat for this process. Then probably some genius in the protein lab was like dude lets just take a natural protein and guide its evolution to serve a purpose that we want it too, its just 2EZ4RTZ. That genius was definitely Artour Babaev. Jokes aside they actually did that and it worked on large-scale proteins unlike the smaller scale ones from before. However Mother Nature was one step ahead of them, and the manufactured proteins were no where near as efficient as the wild types. The way they guide these proteins is by introducing mutations to change the proteins function. This is my angle, I one up the Artours and figure out whether these mutations actually significantly affect certain areas over others. However this is where topic two is gutting me.

My professor, greatest person in the world btw (I mean what professor is kind enough to let a 15 year old join her lab), has been sick all week. This means she definitely isn’t in the office taking care of her grad students. So she’s coordinating emails with them and me. We tried to set up this Saturday morning but it didn’t work out, so I sent her an email about her second available time this Monday afternoon. She is usually godspeed with anything I do, so this illness is pretty serious. I know the general area of research, hell I even know how to do my primary research with the ASU Supercomputer, but I really need the help with my research topic and why LAC1 and other questions. Also I kind of need her original research paper, the paper closest to my topic. It’s kinda like not free online. But maybe she even has an entirely different topic of research ready for me to dive into (in the protein folding field of course).


So to recap, I figured out real world applications and the surrounding field, but I really need to organize this meeting with my professor. My plan moving forward is look into the research on my own and organize the meeting. In terms of struggling, the field is pretty specific with some studies in academic conversation with each other, so I plan to expand my search area into protein folding in general to set up the significance of my future research. So like fingers crossed this meeting happens SOON.
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4 comments:

  1. Ashwath, first, you're better THAN this: "these proteins are significantly less efficient then the wild types (originals)."

    Second, I'm totally unfamiliar with this meme. It's making me feeling at once like an old lady and a n00b.

    Third, you're hilarious.

    Finally, I'm glad that you secured a meeting with your professor this afternoon. I'm happy that you have an expert who is totally responsive to you and available to you -- it'll really help ensure your success. I also liked your explanation of the real-world implications, but I still don't understand why the efficiency of man-made proteins matters. What are some of these man-made proteins? Why do they need to be efficient? What happens when they're inefficient? What are the uses of these proteins? Help!

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  2. Ashwath? Doing Research??? In a LAB?! WITH A PROFESSOR?!?!?! Wow v proud, v proud. But like honestly, I think you’re pretty on top of your game. You know exactly what you’re doing, what research papers to read, you already have a professor to guide you and everything, and you can even include those dank memes in what would otherwise be a very serious research topic.

    So when you say “maybe she even has an entirely different topic of research ready for me to dive into (in the protein folding field of course)”, it kind of sounds like your professor is the one that’s deciding what research topic you’re going to be doing, which is not good??? So how are you going to decide which topic you are going to do? Are you just going to do whatever you or professor wants you to do? Like do you have that choice, or is it just like do what your professor tells you? Also I’m confused about what your 2 topics are because you talked about protein folding and mutations and LAC1 or maybe I’m really bad at comprehension but like can you be a little bit more specific about what you have to do besides meeting with your professor?

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    1. I meant like if my og plan that interests me fails, she'll have some other options.

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  3. First of all, your meme game was pretty week this time. Check out my blog to see what real memes are like. Second, the semi-coherent fragments jumping from one idea to the next really captured the cryptic essence of your being.

    Savagery aside though, I feel like you have a solid understanding of what you at least want to research and have a fairly narrowed field of inquiry (the structure and function of protein folding). I know that you seemed a little worried about not being able to discuss with your professor about your topic, but if she is as godly as you say she is, then I do not think that you should have a problem.

    The only concern that I think that should be brought up right now is the same as what lucia said about the part where you said that your professor might have something else for you. I know she stressed this, but I just want to further emphasize that this is your research project not hers, and so you should do a project on what you are interested in, not what your professor wants you to do.

    Anyways, I just wanted to wrap this up by saying that my favorite line was "Eventually scientists were like wtf we can’t create any proteins we gotta find a cheat for this process." This genuinely made me lol. Lastly, I'm disappointed that you forgot harambe. you should be ashamed

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