This week I attended a Model United Nations conference where I was Venezuela working with the Security Council on issues such as the South China Sea and Syria. It was a double team event, so I had a partner. His name was Amaan. I basically did all the talking, and Amaan did the writing.
In terms of my research, I am still waiting on my min12 results. The final step is just not coming together for whatever reason. Hopefully I can get it fixed in a timely manner. In preparation of a late arrival, I will write a results section based on the Lac1 data I have prepared. JUST KIDDING I JUST CHECKED IT AND I HAVE THE RESULTS BACK!!!!!!!!!!!!!!!
And before I leave, let me hit you with the To Be Continued meme. It basically stops a situation right and the climax, leaving you wanting more. The origin is from the Jojo's Bizarre adventure cliffhangers. Check a compilation out here.
 |
| When you hate the errors in CPUs holding you back |
For the topic of this blog post, I was tasked with analyzing the discussion sections of my discipline. The three papers I decided to look at were Subdividing Repressor Function: DNA Binding Affinity, Selectivity, and Allostery Can Be Altered by Amino Acid Substitution of Nonconserved Residues in a LacI/GalR Homologue, The Role of Conformational Dynamics and Allostery in the Disease Development of Human Ferritin, and Rheostats and Toggle Switches for Modulating Protein Function.
The first paper delved into the evidence by analyzing the flexibility of the linker region of Lac1. It talked about locking, binding affinity, and overall 3D descriptions. Then the writers moved into more theoretical extrapolations about reverse evolution. It seems to analyze the effects of their trials to each of the 3 regions of Lac1. It may be easier to explain if I walk through all 3 sections of a chimera in a similar fashion. But even after that it talks about future applications like Protein Engineering and in Vivo and in Vitro Functions. These really hook the reader, so it will be useful to add the analysis in.
The second paper was very focused on the use of DFI. The discussion was heavily linked to the DFI evaluations. I think I should try to combine the DFI analysis from the second paper with the extrapolations from the first.
Finally the third paper was extraordinarily technical in its discussions. Similarly to paper one, it did look into several different extrapolations. But the literature was so technical that the average reader would get lost in trying to understand the reading.
So my discussion section will focus on the DFI for each of the three protein regions first with 3D protein descriptions, then it will delve into the implications for the analysis.
And before I leave, let me hit you with the To Be Continued meme. It basically stops a situation right and the climax, leaving you wanting more. The origin is from the Jojo's Bizarre adventure cliffhangers. Check a compilation out here.
Hey Ashwath I definitely think it would be helpful to focus on one region at a time. I think that will be more clear for the reader. However, how are you going to justify which extrapolations to talk about for each region? Also what kinds of implications are you planning on discussing?
ReplyDeleteComment is a little sparse, Grace.
DeleteHey Ashwath! Hope you had fun at MUN. It's really great that you've already identified your avenues for future research. While your topic is really interesting, it's also really academically dense, so I think that focusing on one region at a time will definitely make it easier to understand what's going on. I do agree with Grace, though, in the sense that I think you need to explain the implications you'll discuss and justify the extrapolations. That'll be really important in solidifying your establishment of significance. Great work so far!
ReplyDeleteWHATS UP ASHWATH!!!!! i absolutely loved spending time with you and others at MODEL UN BERKELEY! It was such a blast and I cannot wait for AZMUN at U of A two weekends from now! Anyway, I definitely agree with Grace. I think that first, you need to find a way to clearly and effectively organize the loads of data you just received. Organizing it well will allow you to see the trends and easily analyze the data. Once you do that, I think it is of paramount importance to conduct your statistical tests on your new data and delve specifically into why you received the data that you received for the statistically significant data. In order to do so, I think it is best to look specifically at each of the three regions in order to discover the nuances and characteristics that made each region stand apart from each other! Also in the discussion section you need to talk about limitations. What are your limitation?
ReplyDeleteThanks,
Ved Narayan
I think your description of the discussion sections is mildly esoteric as well as vague (which is difficult to be both of those things at the same time). I'm not seeing precisely what you'll talk about or how it relates to your discussion (because it's vague and highly technical in its speech).
ReplyDelete