Monday, October 3, 2016

Episode 8: Let the proteins fold, Energies flow, It feels cold, Going real slow

The meme world has been rocked by the Anti Defamation League. Pepe the frog has been branded as a race symbol by the ADL, due to alt-right individuals using it in a hateful way. However, in the definition provided by the ADL itself they specify that most Pepes are unbigoted. So is it unnecessary to brand Pepe as a hate symbol if a small group of people use it in a racist way. RIP Pepe 2010-2016.

I was asked a few questions about where I am on my research project. I thought I'd answer them here. I am feeling really confident about my method of analysis, excited about researching, and happy that I have useful sources. I am super confident about my method and my project after Oct 22nd. I am very informed on the protein I am investigating and the historical progression of protein folding. I'm pretty excited to get to the work and run the trials, but I got this lit review in front of me. This is something scientists don't really do unless its a giant report, so it is intimidating to finish.

Driving in neutral is the significance of the project and my research question. I feel like I can make a decent significance for my analysis of mutations of LAC1 affecting its dynamic structure (if I mutate this protein how does it affect its flexibility, and how does that flexibility affect the function of LAC1). My research question is also in neutral again, because I need to figure out the metrics of my analysis methods and why I am looking at certain positions. I probably need to manage my time slightly better, but I am juggling my college apps with my other homework right now. I need to buckle down and knock this things out this week.

I feel terrible about the literature review. I need to make a connection between what a protein is and why it matters. Then I need to connect that to the history of protein folding and the introduction of dynamics to the study. I am pretty terrified of how to organize my literature, but I guess that is what the outline is for. Hopefully I can talk to someone this week sooner or later, because I am terrified of that also. I plan to finish a decent outline of what I currently have by Tuesday, so I need to get feedback on this so I can carry on without doubts about my foundation. Because I don't wanna be that guy a week before its due realizing that half of the work I did is useless (like how I felt leading up to the bibliography (I scraped at least 11 sources)).

3 comments:

  1. Ashwath,
    I think it is greta that you are really excited to move forward with your research and that you are confident in your methods. In regards to your lit review, it seems like a case of you not being ready to buckle down and get it done rather than you being unable to do it. I am not very familiar with your project, so I probably won;t be of much help suggesting organization to your lit review, but I will do it anyways. From what I know, I think you need to start by talking about how lactose intolerance is so widespread and an important issue to look at because that draws the reader in and makes them interested in what you are saying from the start. Then you need to generally discuss protien mutations and then specify what you know more to Lac-1. Hopefully that was somewhat helpful. I'm sure you will kill it.
    RIP Pepe

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  2. Ashwath, most importantly, you need to reach out and seek help when you're feeling lost. You have not advocated for yourself for a meeting with me. I don't even know what off periods you have. Therefore, saying "I hope I can talk to someone" is not well-received, as I've seen no effort from you. This is a class where you get out of it what you put into it, so if you can't advocate for yourself, your project will undoubtedly suffer.

    What's happening on October 22nd?

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  3. Ashwath, I have to agree with what Max and Mrs. Haag said. While I am happy that you are enthusiastic about doing your primary research, you really need to be focusing on your literature review. From what I have read, it seems like your literature review is something that you are not looking forward to doing, and as a result you have procrastinated working on it. That being said, you should probably get on that.

    Shade throwing aside though, I think that it is good that you have useful sources and that you are well informed about your source. Since you have those two parts, I think that you should be able to put together a fairly decent preliminary research question.

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